Technical Articles

5-乙炔基尿苷:一种具有生物正交标记潜力的mRNA治疗用核苷类似物
5-Ethynyluridine: A Nucleoside Analog with Bioorthogonal Labeling Potential for mRNA Therapeutics
发布时间 2026-01-15
To evaluate the impact of EU modification on mRNA function, the study synthesized YFP-encoding mRNAs with all uridines replaced by EU, Ψ, m1Ψ, or unmodified uridine (U).
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  • Stem Cells
  • Labeling EU
  • Nucleotide analog
  • mRNA
H-2Kb MHC四聚体揭示免疫途径对mRNA疫苗诱导肺驻留记忆T细胞分化的调控机制
H-2Kb MHC Tetramer Uncovers Immune Pathways Regulating mRNA Vaccine - Induced Lung - Resident Memory T Cell Differentiation
发布时间 2025-05-12
mRNA vaccination has multiple immunological advantages. It can activate CD8 + T cells and CD4 + T cells and induce antibody production, forming an adaptive immune response network. It doesn't rely on viral - vector delivery systems, avoiding the potential limits of pre - existing vector immunity on booster vaccination. Also, the modular design of its industrial production process enables rapid large - scale preparation.
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  • Immunity/Inflamma
  • H-2Kb MHC tetramer
  • mRNA
  • T cells
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