Technical Articles
mRNA
5-Ethynyluridine: A Nucleoside Analog with Bioorthogonal Labeling Potential for mRNA Therapeutics
To evaluate the impact of EU modification on mRNA function, the study synthesized YFP-encoding mRNAs with all uridines replaced by EU, Ψ, m1Ψ, or unmodified uridine (U).
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- Stem Cells
- Labeling EU
- Nucleotide analog
- mRNA
H-2Kb MHC Tetramer Uncovers Immune Pathways Regulating mRNA Vaccine - Induced Lung - Resident Memory T Cell Differentiation
mRNA vaccination has multiple immunological advantages. It can activate CD8 + T cells and CD4 + T cells and induce antibody production, forming an adaptive immune response network. It doesn't rely on viral - vector delivery systems, avoiding the potential limits of pre - existing vector immunity on booster vaccination. Also, the modular design of its industrial production process enables rapid large - scale preparation.
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- Immunity/Inflamma
- H-2Kb MHC tetramer
- mRNA
- T cells
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