Technical Articles

The activin receptor type IIB (ActRIIB) is a pivotal signaling hub in the transforming growth factor-β (TGF-β) superfamily. Far from being a simple receptor, it serves as a "master switch" regulating muscle growth, erythropoiesis, and systemic metabolic homeostasis.

ActRIIB (Activin Receptor Type IIB) is a key signaling receptor in the TGF-β superfamily, serving as the "core negative regulator" of muscle growth and playing a decisive role in muscle atrophy diseases, anemia, and metabolic disorders.

Activin A, a key member of the TGF-β superfamily, is a dimeric protein formed by two βA subunits linked via disulfide bonds. This critical signaling molecule plays a central role in physiological processes such as embryonic development, tissue repair, and immune regulation, but its dysregulation has also become a pivotal factor in the pathogenesis of various diseases.

Activin A is a secreted protein belonging to the transforming growth factor-β superfamily. Like other well-known family members such as TGF-β and BMPs, it plays a central role in cell growth, differentiation, and apoptosis.