Technical Articles

Osteoclasts are the only specialized cells in the human body responsible for bone resorption, and their differentiation, activation, and survival are strictly regulated by a sophisticated cytokine network.

M-CSF, or macrophage colony-stimulating factor, is a key regulator in the hematopoietic system that determines the fate of mononuclear macrophages. It is far more than just a "growth factor" for macrophages; it is the "supreme commander" of their survival, differentiation, and function.