Technical Articles

CDKs (cyclin-dependent kinases) are a crucial class of protein kinases. Their activity is positively regulated by cyclins and negatively regulated by CDK inhibitors (CKIs). The fluctuations in their activation state can be modulated through transcriptional and post-translational modifications (typically phosphorylation), as well as the rapid turnover of cyclins and CKIs mediated by the ubiquitin-proteasome system.