Technical Articles

The MHC HLA-A*11:01/VVVGADGVGK KRAS G12D Tetramer-PE is a rigorously validated high-sensitivity detection reagent, specifically designed for the precise identification and quantification of neo-antigen-specific CD8+ T cells targeting the KRAS G12D oncogenic mutation in human samples.

The MHC H-2K(d)/IYSTVASSL Influenza HA Tetramer-PE is a high-sensitivity reagent specifically designed for detecting influenza virus-specific CD8+ T cells. Utilizing optimized tetramer technology, this product enables precise identification of T cells targeting the influenza virus hemagglutinin antigen in BALB/c (H-2d) mouse models, providing a reliable solution for infectious immunology research.

In the adaptive immune response, MHC-Ia molecules are crucial for antigen presentation and CTL activation. While studies often focus on their classical role, a PNAS study by Shi Yufang and Wang Ying's team at the Chinese Academy of Sciences reveals new insights into the interaction between non-classical MHC-Ib molecules and CD8+ T cells.

Antigen - specific T cells are central effector cells of the adaptive immune system. They play a key role in viral infection, tumor immunosurveillance, and vaccine - induced protective immunity. Traditional detection methods, limited by low sensitivity or complex procedures, struggle to precisely quantify low - frequency antigen - specific T cells. The H-2Db MHC tetramer technology has broken through this barrier. By forming high - affinity polymeric complexes, it enables single - cell detection and functional analysis of CD8+ T cells.