Technical Articles

MPK-5, also known as ERK5 (Extracellular Signal-Regulated Kinase 5), is a pivotal member of the MAPK family, distinguished by its conserved structure and functional versatility. This review systematically elucidates the molecular architecture of MPK-5, its signaling transduction mechanisms, dual roles in plant stress resistance and cancer regulation, and its therapeutic potential as a drug target, providing a theoretical foundation for cross-disciplinary research.