Lure the enemy into a trap and cut off their retreat: How RIPTAC makes tumor cells "cut off their own arm"
RIPTAC (Regulated Induced Proximity Targeting Chimeras) are a class of heterobifunctional small molecules composed of three parts: one end binds to a tumor-specific target protein (Target Protein, TP), the other end binds to a ubiquitously expressed cell survival essential protein (Effector Protein, EP), and the two are connected by a chemical linker.
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