The Fc Receptor Family: The "Superhero League" of Immunotherapy!
Fc receptors are a class of cell surface proteins capable of specifically binding to the Fc segment of immunoglobulins (Ig). They are widely expressed on immune cells, including B cells, T cells, macrophages, dendritic cells, and NK cells. By binding to the Fc segment of antibodies, Fc receptors transmit various signals to regulate the activation, proliferation, and effector functions of immune cells.
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The Fc Receptor Family: The "Superhero League" of Immunotherapy!
On the stage of immunotherapy, the Fc receptor family is undeniably the "Superhero League"! They not only showcase their prowess in modulating immune responses but also play an indispensable role in the development and optimization of antibody drugs. Today, let us embark on a journey into the world of Fc receptors and discover how Uprotein empowers your research with these "superheroes"!
Fc Receptors: The "Signal Hubs" of the Immune System
Fc receptors are a class of cell surface proteins capable of specifically binding to the Fc segment of immunoglobulins (Ig). They are widely expressed on immune cells, including B cells, T cells, macrophages, dendritic cells, and NK cells. By binding to the Fc segment of antibodies, Fc receptors transmit various signals to regulate the activation, proliferation, and effector functions of immune cells.
Fcγ Receptors: The "Right-Hand Men" of Antibody Drugs
In the development of antibody drugs, the role of Fcγ receptors is particularly prominent. By optimizing the interaction between the Fc segment of antibodies and Fcγ receptors, the efficacy and safety of antibody drugs can be significantly enhanced. For instance, FcγRIIIa (CD16a), a key receptor on NK cells and macrophages, mediates antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), aiding the immune system in eliminating tumor cells.
Uprotein: Your Optimal Choice!
Uprotein offers high-quality Fc receptor and Fcγ receptor proteins, all of which have undergone rigorous validation and exhibit exceptional performance.
FcγRIIa (The "Key Player" in Regulating Immune Responses)
FcγRIIa (CD32a) is another crucial activating receptor widely expressed on myeloid cells and platelets. It plays a pivotal role in modulating immune responses and clearing immune complexes.
FcγRIIb (The "Balancer" of Immune Responses)
FcγRIIb (CD32b) is the sole inhibitory Fcγ receptor, predominantly found on B cells and myeloid cells. It transmits inhibitory signals to regulate the intensity of immune responses and prevent excessive activation.
FcRn (The "Guardian" of Antibody Drugs)
FcRn (neonatal Fc receptor) also plays a significant role in the development of antibody drugs. It extends the half-life of antibody drugs, thereby enhancing their efficacy and reducing the frequency of administration.
The Fc receptor family, these "superheroes" of immunotherapy, is ushering in a brand-new era. And Uprotein is your ultimate companion in this era. Let us join hands and harness the power of science to safeguard human health!
Currently Available Products:
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Product Code |
Product Name |
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Fc γ RIII/CD16 His Tag Protein, Cynomolgus |
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Biotinylated Fc γ RIIIa/CD16a(F176) Avi&His Tag Protein, Human |
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Fc γ RIIIb/CD16b(NA1) His Tag Protein, Human |
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UA020011 |
Fc epsilon RI α His Tag Protein, Human |
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UA010430 |
Biotinylated Fc γ RIIa/CD32a(H167) Avi&His Tag Protein, Human |
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UA020015 |
Fc γ RIIB/CD32b His Tag Protein, Mouse |
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Biotinylated Fc γ RI/CD64 His&Avi Tag Protein, Mouse |
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UA010383 |
FcRn His Tag Protein, Mouse |
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FCAR/CD89 His Tag Protein, Human |
This article is reviewed and published by the technical expert team of UA
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