Targeting KRAS G12D Mutation: Breakthrough Application of HLA-A*11:01-Restricted Tetramer-PE in Tumor Immunotherapy Research
The MHC HLA-A*11:01/VVVGADGVGK KRAS G12D Tetramer-PE is a rigorously validated high-sensitivity detection reagent, specifically designed for the precise identification and quantification of neo-antigen-specific CD8+ T cells targeting the KRAS G12D oncogenic mutation in human samples.
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Product Overview
The MHC HLA-A*11:01/VVVGADGVGK KRAS G12D Tetramer-PE is a rigorously validated high-sensitivity detection reagent specifically designed for the precise identification and quantification of KRAS G12D neoantigen-specific CD8+ T cells in human samples. Utilizing optimized tetramer technology, it provides a reliable tool for tumor immunology research.
Core Technical Advantages
Precision Specificity Recognition
Strictly matches HLA-A*11:01 allele
Specifically recognizes the KRAS G12D mutation epitope (VVVGADGVGK)
Excludes cross-reactivity with wild-type KRAS
Outstanding Detection Performance
PE labeling delivers ultra-high signal-to-noise ratio
Detects rare T cells with frequencies as low as 0.001%
Stable tetramer structure ensures reproducible experimental results
Comprehensive Solution
Suitable for various sample types (PBMC, TIL, tumor tissue)
Compatible with multicolor flow cytometry panels
Supports cell sorting for subsequent research
Main Application Areas
Tumor Immunology Research
Detection of KRAS G12D mutation-specific T cells
Analysis of T cell functional states (exhaustion, memory subsets)
Monitoring immune responses in tumor microenvironment
Immunotherapy Development
Quality control of TCR-T cell therapy products
Evaluation of neoantigen vaccine immunogenicity
Monitoring efficacy of immune checkpoint inhibitors
Translational Medicine Research
Immune monitoring in cancer patients
Development of therapeutic response biomarkers
Research on drug resistance mechanisms
Experimental Protocol Features
Standardized Process
Ready-to-use reagent with simple operation
Optimized staining protocol, completed in 30-60 minutes
Strict control settings ensure reliable results
Professional Technical Support
Detailed experimental protocols and troubleshooting guides
Personalized panel design recommendations
Support from a professional technical team
Product Specifications
| Item | Specification |
| Storage Condition | Store at 2-8°C protected from light |
| Size | 100 tests |
| Purity | >95% |
| Compatible Samples | Human cells |
Why Choose Us
Stringent QC: Each batch is functionally validated
Exceptional Performance: High sensitivity for rare T cell detection
Professional Support: Comprehensive technical support from expert team
Complete Solution: End-to-end solution from detection to analysis
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