Wnt signaling is a key signaling pathway that controls a wide variety of cell fates, such as cell movement, polarity, and differentiation during developmental processes, and regulates the homeostasis of adult tissues. Therefore, abnormal regulation of Wnt signaling results in developmental disorders and various human diseases, including cancer.

The canonical pathway regulates the expression of various genes via β-catenin stabilization and the noncanonical pathway is known to regulate a number of cellular processes, such as cell polarity and fate decision.

The Wnt lipoglycoproteins form a family of 19 secreted ligands that are recognized by 10 Frizzled receptors (FZD1–10), G protein-coupled receptors that associate with various coreceptors. Wnt ligands and their receptors participate in numerous possible ligand/receptor/coreceptor interactions and signal through different downstream pathways, which have been divided into three branches; these branches include the β-catenin-dependent or WNT/β-catenin pathway and an additional network of β-catenin-independent pathways, such as planar cell polarity (PCP)-like signaling pathways and G protein-dependent signaling pathways.

Wnt-3a Protein, Human

生物活性

电泳(SDS-PAGE)